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416 As discussed above, ERAD plays a crucial role in maintaining both the quality and quantity of proteins at the ER and is tightly interconnected with the UPR, ER-phagy, and other cellular stress programs

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aeruginosa , the MexR repressor senses oxidative stress (two Cys residues form disulfides), dissociates from the mexAB-oprM promoter, and derepresses efflux under peroxide stress

This results in the pigment clustering up into small groups under various parts of your skin