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doi: 10.1007/s10545-012-9525-7

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Another disadvantage of QSAR models is that the derived estimation may ultimately refer to the metabolite rather than the parent compound as it does not take into account the metabolism that the xenobiotic may be taken in by the placenta

The role of glia in the physiology and pharmacology of glucagon-like peptide-1: implications for obesity, diabetes, neurodegeneration and glaucoma