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G protein coupling In our model of the GLP-2RG s complex, G s protein is anchored by the 5 helix of G s (GH5), thereby fitting to the cytoplasmic cavity of the transmembrane domain (TMD) involving TMs 2, 3, 5, 6, and 7 (Supplementary information, Fig

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Cholesterol is a plasma membrane enriched lipid with pivotal roles in the control of membrane fluidity and maintenance of membrane microarchitecture, directly impacting on GPCR stability, dynamics and function