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Curto M, Butassi E, Ribas JC, Svetaz LA, Corts JCG

When ROS-induced MOMP occurs, cytochrome C enters the cytoplasm and is linked to apoptotic protease-activating factor-1, followed by the activation and release of caspase-3/9, which in turn contributes to morphological changes such as apoptotic body formation, chromatin condensation, and DNA fragmentation [92]