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Emerging research has also highlighted the critical role of epigenetic and post-transcriptional regulation, particularly through microRNAs (miRNAs), which serve as key modulators of immune responses and microbial interactions in IBD, influencing not only immune modulation but also iron metabolism, oxidative stress, and epithelial integrity, all of which are critical to ferroptosis in IBD (94, 95)

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Encapsulation of DSP resulted in a pharmacokinetic profile that showed a 2.3-fold increase in AUC and extended mean residence time, thereby enhancing the potential for nanoparticle extravasation into sites of inflammation via the EPR effect

Brady WJ Jr, Duncan CW