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Animal and human research suggest that increased activity of the endocannabinoid system may lead to insulin resistance, glucose intolerance, and obesity

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2018;315:L1003L1014

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Thus, results from multivariate analyses of large datasets do not provide a valid basis for asserting that early exposure to APAP might be safe for neurodevelopment.The first study to indicate that pediatric use of APAP is associated with ASD was a survey-based, case-controlled study published by Schultz et al