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Similarly, another study found that semaglutide treatment resulted in approximately a 39% decrease in calories consumed from high-fat, high-sugar items (Gibbons et al., 2021)

At the transcriptional level, HMGB1 is also the direct mRNA target of miR-129 (96), while lncRNA ZFAS1 could competitively bind to miR-129 to induce HMGB1 expression

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