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Phase 2 trial data (Jastreboff et al., NEJM 2023) demonstrated average weight reductions of approximately 1724% over 48 weeks notably higher than currently approved GLP-1 receptor agonists such as semaglutide, though direct comparisons are limited by differences in trial populations and designs

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More specifically, orforglipron is a potent partial GLP-1 RA which is biased towards G-protein activation over to -arrestin recruitment at the GLP-1 receptor [23]

When administered, the peptide binds to the GHS receptors in the pituitary gland, triggering the release of GH to help reduce visible aging , enhance recovery, and increase muscle mass