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Ozougwu J, Obimba K, Belonwu C, Unakalamba C

Lesion delineation The MRgFUS lesions were manually delineated based on T1w and T2w images by a radiologist who was blinded to patients clinical information using MRIcro (www.mccauslandcenter.sc.edu/mricro/)

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Taken with that caveat, it fits the idea that central GLP-1 receptor activity crosses an exposure threshold beyond which dopaminergic reward circuitry is damped enough to produce real depressive symptoms in vulnerable people ( 5.2 Neurobiological mechanism GLP-1 receptors in the hypothalamus, prefrontal cortex, and amygdala modulate serotonin, dopamine, and glutamate release