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Over time, patients may experience a turning in of the knees, known as valgus deformity, and advanced arthritis that eventually requires joint replacement surgery

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The drugs work by mimicking the effects of a hormone which regulates appetite, insulin secretion, and glucose metabolism, effectively reducing hunger and increasing feelings of fullness

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Safety Delay In the 1970s, the Food and Drug Administration appointed an expert panel to review the safety and efficacy of over-the-counter pain relievers, including acetaminophen, the active ingredient in Tylenol