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In practice, the long-acting GLP-1 RAs became preferred for general glycemic control due to convenience and greater A1c reduction, whereas short-acting ones like lixisenatide found a niche in combination products or for targeting post-meal glucose excursions (for instance, some use lixisenatide mainly to handle breakfast hyperglycemia)

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For targeting alveolar macrophages, mannose is widely utilized owing to its interaction with the macrophage mannose receptor 1 (also known as CD206) on macrophage surfaces, making it a popular choice in pulmonary drug delivery applications 221,222 , including LNPs 223 , solid LNPs 223,224 and other lipid nanoformulations 225

Follow-up Repeat broad markers after 6-12 weeks if symptoms change, inflammation is part of the context, or the protocol continues