Over up to seven years of follow-up, those treated with semaglutide or tirzepatide had a 37% lower risk of developing dementia (hazard ratio [HR] 0.63, 95% CI 0.500.81), a 19% lower risk of stroke (HR 0.81, 95% CI 0.700.93), and a 30% lower risk of all-cause mortality (HR 0.70, 95% CI 0.630.78), compared to those on other antidiabetic drugs
In contrast, the available human data in BED do not show a reliable alteration of fasting or postprandial GLP-1 levels
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