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Significant impairment of biliary copper transport can permit copper accumulation in the liver
A protocol can involve daily or near-daily dosing over several weeks, so a single combined injection halves the number of injections, simplifies site rotation, and tends to improve adherence
Mechanistically, PBM activates CCO, triggering synergistic anti-inflammatory, immunomodulatory (e.g., macrophage polarization), antioxidant, and pro-autophagic responses that collectively protect cartilage and subchondral bone
Bumps and Pimples: Small red solid bumps or pus-filled pimples often develop