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Neelakantan et al., Biochemical Pharmacology, 2018, gave diet-induced obese mice the compound and reported it significantly reduced body weight and white adipose mass, decreased adipocyte size, with food intake unchanged (PMID 29155147) [3]
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The FDA-approved labels for these agents list nausea, vomiting, and decreased appetite as common adverse effects, though taste alterations are not prominently featured in US prescribing information for most of these medications
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