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Acid Reflux as a Reported Side Effect in Clinical Trials Data from Zepbound and tirzepatide clinical trials recorded acid reflux or heartburn in approximately 9-15% of participants at therapeutic doses, with higher rates reported in some real-world observational studies

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Relative muscle size (normalized to body weight) was not negatively affected

Ginger tea or ginger chews can also help reduce nausea

Together, these hormones help regulate blood sugar levels, slow gastric emptying, and reduce appetite, which can lead to consistent calorie reduction over time