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This synchronized approach triggers an amplified, pulsatile release of endogenous growth hormone that far outpaces the mathematical sum of either compound evaluated in isolation

In an in vivo study, the acute treatment with GLP-1 in female rats resulted in the increase of the amplitude of the preovulatory LH surge, likely by the activation of the kisspeptin hypothalamic system, a key regulator of the pulsatile release of GnRH from GnRH neurons [35]

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Pre-existing gastrointestinal conditions can impact response

The researchers found that participants taking semaglutide had a tendency to experience mild dehydration due to increased urination and reduced thirst