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1.2.1 The main issue is optimization of drug bioavailability The main issue for any formulation of niclosamide (and indeed other BCS Class II and IV low water-solubility drugs) is how to optimize local bioavailability

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When your 40 trillion cells can't process environmental and metabolic demands efficiently, both chemical sensitivity and MTHFR-related symptoms emerge from the same overwhelmed cellular systems

[8] [4] GST proteins are globular proteins with an N -terminal mixed helical and beta-strand domain and an all-helical C -terminal domain

doi: 10.5555/uri:pii:002221438990190X 85 Di LodovicoLRomanoLMartelliGZaccariaMRossiAPetrucciIet al