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The principle of this reaction is based on the reaction between the thiol group (-SH) of glutathione and the DTNB reagent, which results in the formation of a colored product

The primary endpoint measured the percentage of subjects achieving clinical remission at week 12, while secondary endpoints included clinical response rates, symptomatic relief, endoscopic remission, mucosal healing at weeks 12 and 52, plus quality of life assessments using IBDQ and SF-36 scores at multiple timepoints including weeks 24 and 64 during extension treatment

Paracellular routes by TJ modulation and transcellular routes by membrane perturbation are often regarded as two separate mechanisms

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Figure 2 provides an integrated overview of ASTs effects on pathological processes relevant to neurodegenerative diseases, including oxidative stress, neuroinflammation, and synaptic dysfunction, which are particularly relevant in AD and PD pathology