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The most honest answer is that tirzepatide may support general health, but it is not a proven lipedema-specific therapy

33 Activity of the thymidylate synthase enzyme is the rate limiting step in this complex, responsible for synthesizing the thymine precursor, thymidylate, during DNA repair

The meta-analysis by Wang and colleagues 137 included an unpublished trial (NCT00845507 145 ) that was not part of the more recent meta-analysis by Khaity and colleagues 134

Benke, D., Honer, M., Michel, C

Safety and tolerability of the ketogenic diet used for the treatment of refractory childhood epilepsy: a systematic review of published prospective studies