In humans, using the same specific sandwich ELISA as applied in this study, GLP-1(936)NH 2 does not seem to be subject to the same rapid degradation, since the GLP-1 secretory profiles obtained with this assay (in response to oral glucose administration) are comparable with those obtained using a single-site C-terminal specific RIA [30]
At the studys initiation, 29% of patients were prescribed semaglutide, 49.7% dulaglutide, 34% liraglutide, 12.7% exenatide, 4.6% tirzepatide and 2.1% lixisenatide
Abd El Aziz MS, Kahle M, Meier JJ, Nauck MA
AmylinIts role in the homeostatic and hedonic control of eating and recent developments of amylin analogs to treat obesity
Any oral tirzepatide product designed to be swallowed, rather than absorbed sublingually, would need bioavailability-enhancing technology similar to or better than the SNAC system used in oral semaglutide