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Environmental Toxins: Exposure to pollutants, heavy metals, and pesticides increases the "toxic load" on your liver, using up glutathione faster

Depending on the amount and type of toxins released and your specific genetic makeup, taking glutathione could cause harm or trigger other health issues

Wasko R, Jaskula M, Kotwicka M, Andrusiewicz M, Jankowska A, Liebert W, et al

It does not have any pain-relieving effect

These findings, along with the fact that the lung can normally maintain GSH for long periods even with the oxidant burden of CS, lend credence to the theory that disease symptoms could arise when adaptive responses fail or are dysfunctional