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In addition, proteins involved in the organization and maintenance of mitochondrial DNA, such as transcription factor A, mitochondrial (TFAM), TWINKLE, and DNA polymerase subunit gamma (POLG), have been found to be succinated, which interferes with mitochondrial DNA replication and maintenance ( 116 )

MASLD: Prognosis and treatments MASLD, formerly referred to as nonalcoholic fatty liver disease, represents a significant global health burden, with rising prevalence and associated risks of fibrosis, cirrhosis, and mortality

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Creatine is the most effective supplement for increasing muscle mass and strength L-Carnitine helps the body convert fat to energy by transporting fats into mitochondria for beta-oxidation and energy production