95,96 Pharmacological agents such as GLP-1 RAs mimic endogenous GLP-1 regulatory activities, aiding in T2D management by increasing the incretin effect, postprandial insulin release, increased satiety, and decreased glucagon secretion, thus improving glycemic control
Its not as potent as GLP1s on average, but its a pill, widely used, and may be a fit if you prefer noninjection options or cant access GLP1s
Kidney Protection Obesity and diabetes often lead to chronic kidney disease, a serious condition that can result in dialysis
Recombinant leptin therapy in these people produces marked reductions in appetite and weight, underscoring leptins central role in energy balance [153]
While there are no specific guidelines for monitoring thyroid health while taking GLP-1s, it's generally recommended to include thyroid function tests in routine screenings to monitor for any changes that might call for further evaluation