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Anticancer Res 37:64976509

Additionally, a double-blind, parallel-group, placebocontrolled trial (considered the gold standard in clinical research) was conducted on 50- to 80-year-old Japanese individuals diagnosed with mild cognitive impairment to examine the efficacy of oral administration (3 gms/day mycelial powder) of Lions Mane ( Hericium erinaceus ) [13] The Lions Mane group showed significantly increased scores on the cognitive function scale compared with the placebo group at weeks 8, 12, and 16 of the trial

The addition of the thiol reductant, dithiothreitol, at the start of phase 2, prevented and reversed the toxicological damage that would otherwise occur, in the absence of any reduction in covalent binding or resynthesis of GSH