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Zhou R, Zhao G, Zheng S et al (2023) Comprehensive functional analysis of the bZIP family in Bletilla striata reveals that BsbZIP13 could respond to multiple abiotic stresses

They tend to be more potent and more toxic than naturally occurring cannabinoids, leading most governmental regulatory agencies to consider them illicit, toxic chemicals

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Available in vitro and in vivo studies show positive exfoliant results but clinical (human) trials specifically on enzymatic exfoliation are still limited at this time