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Increased oxidative stress or deficient antioxidant status is critical in the pathogenesis of rheumatoid arthritis.[60,61] Some antioxidants including SOD and Vitamin E have an anti-inflammatory role in experimentally induced arthritis.[61] It was found that SOD activity is low in patients suffering from rheumatoid arthritis and the administration of SOD through liposomes had a positive effect in the treatment of experimental arthritis.[62,63] SOD and neurodegenerative diseases Oxidative stress has been shown to be involved in the pathophysiology of several neurodegenerative diseases

Hormonal Regulation Peptides alter GnRH, LH, and FSH release of the HPG axis

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Yet that randomized control trial included a more general population, not specifically participants with PCOS