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PMID: 19581535

Hyperphosphorylated tau disrupts microtubules, impeding mitochondrial trafficking to synapses, and accumulates in mitochondria, inhibiting oxidative phosphorylation

In comes the SUSTAIN-7 trial

WaddenJAMA Internal Medicine93 GLP-1RA(FDA)(EMA) Wadden3STEP(Semaglutide Treatment Effect in People With Obesity)12352.4mg/STEP1233,377(491369.6)STEP5304(471177.6) STEP123PHQ-92.02.31.82.3 68PHQ-92.02.92.43.3(estimated treatment difference)0.5695 0.810.32(P0.001)68PHQ-9 0.63 0.500.79P0.001 1STEP5 WaddenSTEP (COI) HealthDay News 202493 Copyright 2024 HealthDay

GLP-1 (glucagon-like peptide-1) receptor agonists, such as liraglutide, semaglutide, and dulaglutide, are medications commonly used to help manage T2D and aid in weight loss