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Effect of elexacaftor/tezacaftor/ivacaftor on mucus and mucociliary clearance in cystic fibrosis

Table S1 in Supplementary material)

Given the biphasic dose-response curve described above for cardiovascular effects, a reconstitution error that doubles the intended dose may shift the patient from a vasodilatory to a vasopressor pharmacodynamic regime

Skipping full discharge tests masks early failure signs

As a member of the emerging class of mitochondrial-derived peptides (MDPs), MOTS-c has attracted significant research interest for its role in mitochondrial-nuclear communication, metabolic homeostasis signaling, and cellular stress response pathways in controlled laboratory settings