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The multiple conformations observed from the single-particle EM analysis of the purified Fab7F38semaglutideGLP-1RGsNb35 complex most likely represent different agonist-bound ECD conformations, however some 2D classes are also compatible with the closed conformation observed in our inactive crystal structure (Supplementary Fig
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For instance, a greasy fast-food cheeseburger and fries might make you feel quite ill on a GLP-1
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