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Surface plasmon resonance analyses provide direct evidence of melittins interaction with these critical upstream signaling molecules, with dissociation constants of 4.6 10 -6 M (IKK ), 1.34 10 -9 M (IKK ), and 1.01 10 -9 M (p50), highlighting its specificity and potency (90, 91)

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Reasons for cancer predisposition on B cell therapies may have to do with the potentially protective role of B cells in tumor microenivronments as APCs and activators of NK and cytolytic T cells targeted toward lysis of tumors