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Atallah E, Grove JI, Crooks C, Burden-Teh E, Abhishek A, Moreea S, Jordan KM, Ala A, Hutchinson D, Aspinall RJ, Murphy R, Aithal GP (2023) Risk of liver fibrosis associated with long-term methotrexate therapy may be overestimated

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Neurological diseases: Glutathione is thought to have an impact on neurological functions

That is a clinically useful result for a short-term, low-cost agent but it is roughly half to a third of what semaglutide achieves over a longer horizon, and phentermine's effect is studied over a much shorter window

Dose escalations: Each time the dose increases, GI symptoms may briefly return