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Incretin hormones, GIP and GLP-1, are released when nutrients (especially glucose and starches) meet special cells in the intestine as food clears the stomach

Comparative GLP-1 agonist pharmacology

Corey Henderson, a molecular biologist who had designed a novel peptide that could interact with GLP1 and GIP receptors in the same way that the drugs do, but in a totally natural way without any synthetics

Gastrointestinal Side Effects Both Zepbound and Metformin commonly cause gastrointestinal side effects such as nausea, vomiting, diarrhea, and constipation, especially when starting treatment or increasing doses

Likely it will increase how much they exercise from none to some, and this will carry some benefit also