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The reduction of MYCN protein levels in MYCN-driven brain tumors is of major importance due to its central role as an oncogenic driver ( In addition to mitochondrial damage, whole proteomic and phosphoproteomic analysis highlighted the impact of our drug combinations on cell cycle blockade and DNA damage as part of their mechanism of action

Artificial pancreas using a personalized rule-based controller achieves overnight normoglycemia in patients with type 1 diabetes