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(115) reported that microbiota-derived metabolites suppress HIF-2, a master regulator of intestinal iron absorption, and increase ferritin levels, thereby limiting host iron uptake and potentially reducing the labile iron pool that fuels lipid peroxidation

In line with these findings, the modest proportion of patients which improved vasculogenic ED degree category included only those patients belonging to the baseline category of mildmoderate vasculogenic ED, which reached PSV values compatible with absence of ED

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Additionally, iTRAQ analysis showed higher amounts of glutathione peroxidase ( BC2114 ), glyoxalases ( BC5092, BC3532 ), superoxide dismutase ( BC4272 ), thioredoxin-dependent thiol peroxidase ( BC0517 ), thiol peroxidase ( BC4639 ), and heme-dependent peroxidase ( BC5388 ) in biofilm-associated cells (Fig