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For more persistent reflux, your healthcare provider may recommend: Alginate-based therapies (such as Gaviscon), which form a protective raft on top of stomach contents Proton pump inhibitors (PPIs) such as omeprazole or lansoprazole, which reduce stomach acid production H2 receptor antagonists like famotidine, offering moderate acid suppression These medications can be used safely alongside Ozempic, though long-term PPI use should be reviewed after 4-8 weeks, aiming for the lowest effective dose in line with NICE and BNF guidance