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Experts previously told Everyday Health that extreme weight loss in less than six months can cause a loss of skin elasticity due to the disruption of the skin barrier and the rapid depletion of the essential fatty acids. The result is a lusterless, thin, drooping complexion

The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus

A recent study by Wang et al

The included nausea meds and education sessions are thoughtful touches

If there is an issue of heterogeneity between studies, a random effects model was utilized to address it