In both HepG2 cells (experimental data) and PHHs (data from TG-GATES), NFT revealed an activation of module 144, showing oxidative stress response as the module ontology (Fig
L--C31
(d) Ferroptosis-targeted therapeutic strategies and future perspectives, summarizing current ferroptosis-directed interventions that encompass pharmacological agents, gene therapy, and cell-based treatments, and examining both the challenges and opportunities of their clinical translation
Biochimie 116:5260 Ma Q, Li Y, Fan Y, Zhao L, Wei H, Ji C, Zhang J (2015) Molecular mechanisms of lipoic acid protection against aflatoxin b1-induced liver oxidative damage and inflammatory responses in broilers
Lipotoxicity-induced reactive oxygen species (ROS) has been known to be a major pathogenesis factor of NASH progression