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Its anti-inflammatory mechanisms are enacted through the downregulation of pro-inflammatory cytokines such as IL-1, IL-6, and TNF-, along with the inhibition of NF-B signaling, thus alleviating neuroinflammation that is implicated in the etiology of depressive disorders (54)

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[See Clinical Studies.] Important Limitations of Use Janumet should not be used in patients with type 1 diabetes or for the treatment of diabetic ketoacidosis, as it would not be effective in these settings