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The calculation procedure can be found in Additional file 1: Fig S2

Other studies reported lactic acidosis and increased alanine levels, it is highly recognized that high concentrations of lactate can inhibit mitochondrial respiration and disbalance the redox equilibrium (Oliveira et al., 2005)

Severe signs requiring medical attention include persistent vomiting or diarrhea, confusion, rapid heart rate, and significant lightheadedness when standing

Leachman, S

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