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In this context, the activity of preproglucagon-expressing neurons in the NTS is stimulated by afferent vagal inputs that relay satiety signals from the periphery to the brain, such as gastric distention, the induction of peripheral GLP-1Rs or the release of the satiety-associated hormones cholecystokinin and leptin

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Interpreting the Evidence Across studies, these findings suggest that GLP-1s may influence biological processes associated with primary hallmarks, particularly epigenetic regulation, inflammatory signaling, and cellular stress responses

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