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Impairment of mitochondrial calcium buffering links mutations in C9ORF72 and TARDBP in iPS-derived motor neurons from patients with ALS/FTD

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Targeting metabolic checkpoints such as PKM2 or succinate oxidation can increase the availability of redox-active metabolites that accelerate lipid peroxidation in tumor cells

Demonstrating proper pen technique (needle attachment, dose confirmation, and safe disposal) helps prevent dosing errors