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PMID: 37051367
In general, although with exceptions, activated endothelial cells act as the initial stimulus, causing the subsequent recruitment of leukocytes which release a host of pro-fibrotic cytokines like IL-6 and TGF-1, which act on local fibroblasts to create a fibrogenic environment, causing the transition from inactive into aberrantly activated SMA expressing myofibroblasts ( ACTA2 and THY1 (encoding for SMA and CD90, respectively), also contribute to the progression of fibrosis (50)
Most reported changes track with how much and how quickly weight shifts, or with improvements in conditions like insulin resistance, rather than with a new uterine pathology
To prevent this, we have evolved to slowly move potassium from our digestive system through the extracellular fluid and into our cells