One potential issue associated with high doses of folic acid is that it has a masking effect on the diagnosis of pernicious anaemia due to vitamin B 12 deficiency, and may even precipitate or exacerbate neuropathy in vitamin B12-deficient individuals
In a similar study of BALB/c mice sensitized to ovalbumin, reductions in the GSH/GSSG ratio in lung tissue after ovalbumin challenge were also associated with increased airway mucin production and airway hyperresponsiveness, which persisted for several days after the initial exposure (249)
However, its possible to manage this side effect with diet and lifestyle changes, as well as over-the-counter (OTC) medicines
Unusual Symptoms : Any unusual symptoms, such as fever, significant muscle weakness, or dark urine, require immediate medical attention
These modifications block DPP-IV and extend the half-life to approximately 30 minutes