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This review examines a broad spectrum of endogenous peptidereceptor systems that regulate metabolism, appetite, bonemusclefat crosstalk, neuroendocrine function, immune modulation, and tissue repair, yet lack approved therapeutic analogs

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200 ALOX15 is intricately linked to the generation of lipid ROS in gastric cancer cells, and miR-522, found in exosomes derived from CAFs within the tumor microenvironment, acts as an upstream inhibitor of ALOX15