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A small number of people in trials had to stop Mounjaro due to side effects (~3% [48] , meaning the vast majority could continue)

The August 2023 announcement of topline results was followed in November 2023 by a presentation of detailed results 7 , which revealed a statistically significant reduction in non-fatal myocardial infarction of 28% and smaller reductions in cardiovascular death and non-fatal stroke which were not statistically significant over the length of the trial (up to five years)

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In pharmacology, half-life represents the time required for a drugs concentration in the bloodstream to reduce by half

Even optimistic estimates, and these are truly generous projections, suggest sublingual bioavailability for a peptide of this molecular weight would fall well below 1%