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Met carriers produce less activity-dependent BDNF and may show poorer episodic memory performance and steeper age-related cognitive decline

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In patients with Long COVID and ME/CFS, neuroinflammation and metabolic stalling often lead to a severe depletion of these critical neurotransmitters, resulting in deep depression, anhedonia, and profound brain fog

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Upon activation, ERK1/2 translocate to the nucleus and regulate transcription factors like MYC, MITF, and AP1 [3]