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This epigenetic reprogramming induces immunosuppressive phenotypes in immune cells that are resident in the tumor microenvironment, including impaired effector function, enhanced immunosuppressive cytokine secretion, and altered tumor antigen presentation, collectively facilitating immune escape
The indications develop slowly and can go unnoticed for a longer period, that keeps it problematic to identify the disease primarily
10.1016/0896-6273(94)90362-x Neuron 44 HolickM
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