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Tubulointerstitial damage is a pathological hallmark of the lupus kidney, and its associated inflammation is critical to diagnose and predict the prognosis of LN ( 4.2 Ferroptosis and rheumatoid arthritis Rheumatoid arthritis (RA) is the typical autoimmune disease that primarily targets the synovial membrane of the joints, resulting in the synovium transforming into a hyperplastic and invasive tissue that destroys cartilage and bone ( Synovium hyperplasia is a key factor in the development of RA, which contributes to cartilage degradation and invasive pannus formation ( Building on the collagen-induced arthritis (CIA) mouse model, Wu et al

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