Since tirzepatide already includes GLP-1 receptor agonism, adding semaglutide would double the GLP-1 stimulation without providing the additional GIP benefit
The relative expression of CYP17A1, StAR, Beclin-1, and LC3B, as well as MDA, were significantly reduced, while CYP19A1, p62, GSH, and SOD were significantly increased
This leads to increased satiety, reduced hunger, and delayed gastric emptying (an effect that may diminish over time), which collectively contribute to significant weight loss
Lifting with a trainer or other professional for at least 10 weeks can add roughly 3 kg of lean mass and improve strength by about 25%, even during a calorie deficit (if you don't have a trainer, a well designed program with progressive overload should do the trick)
Patient information leaflet Always read the PIL supplied with your medicine for the complete list of side effects, warnings, and interactions