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Cardiovascular outcome trials have established benefits for specific agents: the LEADER trial for liraglutide, SUSTAIN-6 for injectable semaglutide, and REWIND for dulaglutide demonstrated reduced risk of major adverse cardiovascular events in patients with type 2 diabetes

In rodents, C-cell hyperplasia is considered a preneoplastic lesion leading to medullary thyroid cancer

Healthcare providers should assess for conditions that increase appetite, including uncontrolled diabetes (check HbA1c), thyroid disorders (TSH, free T4), and psychiatric conditions